مطالعه نقش الیگونوکلئوتیدهای حاوی سیتوزین ـ گوانین در تولید اینترفرون گاما و ایمونوگلوبولین ـ ای در پاسخ به آلرژن کنوپودیوم آلبوم در مدل موشی آسم

Background & Aim: and achieving safe prophylactic and therapeutic procedures is the main aim of the investigators. CpGoligodeoxynucleotides (CpG ODN) which modulate the immune responses and change the cytokine patterns by severalmechanisms are among these procedures.Worldwide increasing number of allergic disorders is one of the most important health challenges,Material and Method: Chenopodium album (CH.a), a common allergenic plant in Iran, in a murine model of asthma. We used CH. a pollenextract with CpG to sensitize the mice and compared a number of immunologic parameters such as interferon gamma(IFN- lung culture supernatants. Histological studies were also conducted to identify inflammatory cells in lung airways. ANOVAtest was used to analyze the data.In this experimental study we investigated the effects of CpG motif on immune responses toγ) and IgE levels between case and control groups. To do this, IFN-γ and IgE levels were measured in splenocyte andResults: by 80% and have a potent influence to augment both systemic and local levels of IFN- The study showed although CpG ODN cannot reduce IgE levels to the normal range, they can lower IgE levelsγ as a Th1 activity marker (P<0.01)Conclusion: reducing lung inflammatory responses. Since CpG components have potency to shift immune activity from Th2 to Th1responses, it seems that co-administration of CpG/antigen can modulate inflammatory responses to different allergenicantigens.The results of the study have consistency with other reports and confirm the benefits of CpG motifs in